Air contamination: a major risk for patients
Air contamination is due to the presence of microorganisms and aerosolized particles that can carry them. Among these, Aspergillus spp. is responsible for invasive aspergillosis, a potentially life-threatening condition for immunocompromised patients. Immunocompetent patients undergoing deep surgery (cardiac surgery), as well as burn and ICU patients, are also at risk. MERS-Cov, MRSA, and multi resistant Mycobacterium tuberculosis are of great concern to clinicians because of their high pathogenicity and the difficult, costly treatment they involve.
PLASMAIR Guardian and Sentinel
are considered a standard for air treatment in hematology, bone marrow transplants units, operating rooms and departments receiving high risk patients.
Today, mobile air decontamination units have demonstrated their ability to effectively replace deficient or inappropriate air treatment systems in hospitals’ high risk areas. Scientific studies have demonstrated that PLASMAIR units equipped with HEPA-MDTM significantly reduced the occurrence of Invasive Aspergillosis (IA) in neutropenic patients with hematologic malignancies2.
Scientifically Proven Efficiency
PLASMAIR Air Decontamination System Is Protective Against Invasive Aspergillosis in Neutropenic Patients
PLASMAIR System Significantly Improves Air Treatment Performance in Operating Room
Seven-Year Surveillance of Nosocomial Invasive Aspergillosis in Hospital Setting
Decreasing Airborne Contamination Levels in High-Risk Hospital Areas Using PLASMAIR
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PLASMAIR HEPA-MDTM technology 4 stages reactor
Destruction of microorganisms
The “MD” in HEPA-MD stands for Microbial Destruction. In this stage, microorganisms are destroyed through exposure to powerful electric fields and oxidative species in unique non-thermal plasma chambers.
The charged particles exiting stage 1 are captured in an electrically active medium. Biological decontamination is achieved through continuous exposure to plasma ions.
Elimination of oxidant chemical molecules
Oxidant chemical species are eliminated through catalytic conversion. In this stage, charged particles are converted into inert molecules.
Adsorption of Volatile Organic Compounds and odours removal
Volatile organic compounds responsible for bad odours are adsorbed onto an activated carbon medium.
1 Sixt N, Dalle F, Lafon I, Aho S, Couillault G, Valot S, et al. Reduced fungal contamination of the indoor environment with the PLASMAIRTM system (Airinspace). J Hosp infect 2007; 65:156-162.
2 The PLASMAIRTM Decontamination System Is Protective Against Invasive Aspergillosis in Neutropenic Patients Fernandez-Gerlinger MP, Jannot AS, Rigaudeau S, Lambert J, Eloy O, Mignon F, Farhat H, Castaigne S, Merrer J and Rousselot P. Infection Control & Hospital Epidemiology, 2016, Vol 37, N° 7. 845-851.
Distributed by: SciCan Ltd., 1440 Don Mills Rd., Toronto, ON, M3B 3P9.
Manufactured by: airinspaceTM 14 rue Jean Monnet, 78990 Élancourt, France.
HEPA-MDTM is a registered trademarks of airinspace.
ORIGINAL ARTICLE: The PLASMAIRTM Decontamination System Is Protective Against Invasive Aspergillosis in Neutropenic Patients
Fernandez-Gerlinger MP, Jannot AS, Rigaudeau S, Lambert J, Eloy O, Mignon F, Farhat H, Castaigne S, Merrer J and Rousselot P. Infection Control & Hospital Epidemiology, 2016, Vol 37, N° 7. 845-851.
Invasive aspergillosis (IA) is the most serious form of aspergillosis, an infection caused by airborne Aspergillus spores. Those at risk of developing IA are immunocompromised patients for whom the infection is often lethal. This study’s aim is to evaluate the impact of a mobile air decontamination system (PLASMAIR) on the incidence of IA in neutropenic patients in a hematology ward.
The clinical study was conducted over a 2-year period in the 15-bed hematology intensive care unit of Hôpital de Versailles, France. A PLASMAIR™ unit was installed in half of the rooms and patients were assigned to PLASMAIR-equipped (PLASMAIR group) or non-equipped rooms (no PLASMAIR group) based on availability alone. Air and surface samples were routinely collected to determine environmental contamination levels in all rooms.
None of the surface samples from PLASMAIR-equipped rooms were positive for fungal load compared to 5.9% of the non-equipped rooms and the rate of air contamination in PLASMAIR-equipped rooms (7.3%) was significantly lower than that observed in non-equipped rooms (19.4%). Data for 156 patients with chemotherapy-induced neutropenia was admitted in the comparison of IA incidence in the two groups. A total of 11 of these patients were diagnosed with probable IA: 10 out of the 69 patients in the no PLASMAIR group and only 1 of the 87 patients in the PLASMAIR group. The odds of developing IA were much lower for patients hospitalized in PLASMAIR-equipped rooms than those in non-equipped rooms.
In this study, the PLASMAIR air decontamination system significantly reduced the incidence of IA in neutropenic patients. The study demonstrated that the PLASMAIR system represent an efficient and convenient alternative to combined use of HEPA filtration and laminar airflow.
ORIGINAL ARTICLE: Assessment of a mobile decontamination unit for air control in operating theatres
Schoenleber T, Gbaguidi H, Juenet L, Talon D, Évaluation d’un dispositif mobile de décontamination pour la maîtrise de l’air au bloc opératoire, HYGIENES, 2007, Vol XV, N°2. 159-163. (English translation)
Surgical Site Infections (SSIs) represent an important challenge in the hospital setting. With bacteria-bearing airborne particles representing the main source of SSI’s, controlling air quality in the operating room is an essential preventative measure. This study’s aim is to assess the efficiency of a mobile air decontamination system (PLASMAIR™) against aerobiocontamination in operating rooms.
The clinical study was conducted at Besançon Hospital, France. Air samples were collected in an operating room both during and after procedures with and without the PLASMAIR. Biocontamination levels, particle decontamination kinetics and the mixing rates of the operating theatre equipped with a turbulent airflow system were measured.
The biocontamination rates during operations or no activity were decreased by a coefficient of about 2.5; the decontamination kinetics was lower than 7 minutes with the PLASMAIR compared to over 10 minutes in rooms without the PLASMAIR; and air change rates increased substantially. The PLASMAIR system also reduced the impact of the number of persons in the operating theatre on biocontamination rates.
The study demonstrated that the PLASMAIR system significantly improves air treatment performance in operating rooms.
ORIGINAL ARTICLE: Seven-year surveillance of nosocomial invasive aspergillosis in a French University Hospital
Garnaud C, Brenier-Pinchard MP, Thiebaut-Bertrand A et al. Journal of Infection, 2012, Vol 65, N° 7. 559-567.
Mortality rates associated with invasive aspergillosis (IA) are high particularly for immunocompromised including patients with hematological malignancies, transplant recipients and intensive care unit (ICU) patients. This study’s aim is to review cases of aspergillosis with a special focus on nosocomial cases in order to evaluate the efficacy of environmental prevention measures (laminar airflow or PLASMAIR™ air decontamination units).
The study was conducted over a seven-year period in the Grenoble University Hospital, France. PLASMAIR units were installed in hematology and cardiac surgery units as well as cardiac, surgical and medical ICUs.
70 probable and proven IA cases were diagnosed. Nosocomial IA accounted for about a third of all IA cases. The 21 nosocomial IA cases all occurred in areas without air treatment (laminar airflow or PLASMAIR™ air decontamination units) or undergoing construction work.
The study demonstrated the efficacy of environmental protective measures such as the use of PLASMAIR units in preventing nosocomial IA. The results also show the relevance of enforcing these measures, especially in hematology units and during construction works.
ORIGINAL ARTICLE: Decreasing airborne contamination levels in high-risk hospital areas using a novel mobile air-treatment unit
Bergeron V, Reboux G, Poirot JL, Laudinet N, Infection Control Hospital Epidemiology 2007, Vol 28, N° 10. 1181-1186.
Decreasing and controlling the level of airborne pathogens in hospitals’ high-risk areas is paramount for reducing the risk of hospital-acquired infections. This study’s aim is to assess the performance of a mobile air decontamination system (PLASMAIR™) in lowering the airborne bioburden and reducing the risk of nosocomial infection from airborne opportunistic pathogens such as Aspergillus fumigatus in critical hospital environments.
The study was conducted in two different high-risk hospital areas: in an operating room (OR) at Saint Antoine Hospital in Paris, France and in the Pediatric Hematology Service at the University Hospital in Besançon, France. Functional tests were performed in the OR where PLASMAIR Guardian units were installed. As for the Hematology Service, clinical tests were conducted over a 12-day period comparing airborne fungal levels in an occupied patient room equipped with a PLASMAIR Guardian unit with the level in an occupied patient room lacking such a unit. Patients were randomly assigned to PLASMAIR-equipped and non-equipped rooms with the same characteristics and level of activity. Air samples were collected to determine environmental contamination levels in both areas.
In the 118 m3 OR, the use of PLASMAIR units decreased the time required to decrease the level of air particles larger than 0.5 μm by 90% from 12 minutes with existing air filtration system to less than 2 minutes. There was an exponential 2-log decrease in the steady-state level of these particles (p < 0.01) and concentration in airborne mesophilic flora decreased by a factor of more than 2. No airborne fungal species were detected while the units were in use in the OR. In the hematology ward, there was a significant reduction in the rate of airborne fungal flora in the PLASMAIR-equipped room (p < 0.01), with an average reduction of 75% of airborne opportunistic flora and 82% of non-pathogenic flora.
The study demonstrated that PLASMAIR can rapidly and efficiently reduce levels of airborne particles and airborne bioburden in high-risk hospital areas including OR and hematology wards.